Time: 2025-11-24
In Path of Exile 3.27: Keepers of the Flame, the Viper Strike of the Mamba Pathfinder has emerged as a dominant force, blending staggering clear speed with boss-melting poison damage. This build leverages Master Toxicist to spread massive poisons across entire packs, while stacking strike range to mimic a ranged playstyle without the fragility.
Whether you're farming juiced T17 maps or shredding Uber Elder in seconds, this guide breaks down everything from leveling to endgame optimization—including a ready-to-import PoB.
This build thrives in the current league mechanics, utilizing grafts to scale chaos damage and Pathfinder’s flask sustain for near-immortality. Below are the key performance benchmarks:
| Aspect | Rating | Details |
|---|---|---|
| Clear Speed | S+ | Poison proliferation and Whithering Step erase packs instantly. |
| Bossing | S | 30M+ poison DPS deletes Uber bosses; Plague Bearer adds burst control. |
| Survivability | A+ | 4k+ life, Spell Suppress, Petrified Blood, and Master Surgeon recovery. |
| League Viability | S | Excels in Breach, Simulacrum, and graft-enhanced cluster jewel setups. |
6-Link Chest (Main Damage):
Viper Strike of the Mamba - Awakened Added Chaos - Awakened Swift Affliction - Awakened Melee Physical Damage - Fortify - Overexertion
Movement & Utility:
Whirling Blades - Faster Attacks - Enhance - Automation
Withering Step - Battlemage’s Cry - Ancestral Cry - Plague Bearer
Defensive & Aura Setup:
Petrified Blood - Flesh and Stone - Blood Rage - Despair (on Hit)
Malevolence - Purity of Lightning - Enlighten
Weapons: Dual-wield Pneumatic Daggers with “Hits Can’t Be Evaded” and high attack speed.
Body Armor: Doppelgänger Guise or a rare ES/Evasion base with life and resistances.
Jewels: Ashes of the Stars, Voices with Low Tolerance, and Watcher’s Eye with Malevolence mod.
Flasks: Progenesis, Quicksilver, and Assuaging Divine Life Flask.
Crafting Tip: Use Harvest chaos rerolls on ilvl 83+ daggers to secure chaos damage and attack speed prefixes.
Ascendancy (Pathfinder):
Master Toxicist → Nature’s Adrenaline → Master Surgeon → Nature’s Reprisal
Pantheon:
Major: Brine King (upgraded)
Minor: Ralakesh
Passive Tree Highlights:
Focus on chaos damage, poison duration, and spell suppression. Utilize cluster jewels with “Low Tolerance” for 300% increased poison damage.
This build excels at clearing high-tier maps and boss encounters efficiently. To speed up your gearing process—especially when targeting mirror-tier equipment—you can buy Path of Exile currency quickly and securely from MMOMAX, a trusted platform for PoE traders.
Run Simulacrums, Breachlord domains, and grafted T17 maps for consistent Divine Orb returns. For players short on time, MMOMAX offers a safe and fast way to buy Path of Exile items and currency, so you can focus on optimizing your Mamba build.