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Path Of Exile 2 Act 4 and Interludes: Complete Campaign Walkthrough & Boss Strategies

Time: 2025-09-02

The Third Edict expansion introduces Act 4, along with a series of temporary Interludes—side stories that bring you back to earlier regions. In Act 4, you’ll explore the islands of Ngamakanui, uncovering the history of the Karui and their ancestral deities while pursuing a legendary artifact called the Third Edict. The Interludes return you to Ogham and the deserts of Vastiri, eventually leading you on a mission for Doryani—all amidst the spreading corruption of the Beast. Dive deeper into these adventures with our updated campaign walkthrough and detailed boss guides for both Act 4 and the Interludes.

Act 4 Walkthrough
Set sail for Kingsmarch in pursuit of an ancient weapon capable of confronting the corruption—the instrument known as the Third Edict. The Ngamakanui islands are rich with Karui tradition, so stay alert for glimpses of their ancestral gods as you journey through each zone. This act unfolds across a variety of compact regions, each with distinctive environments, enemies, and narrative elements. You might stumble upon goblins paying homage to a local giant on one island, while another conceals an ancient horror waiting to be unleashed.

You’re free to tackle the following locations in any order:

  • Isle of Kin

  • Kedge Bay

  • Abandoned Prison

  • Whakapanu Island

  • Shrike Island

  • Arastas

  • Ngakanu

As you progress through Act 4, you’ll also gain access to:

  • Eye of Hinekora

  • Plunder’s Point

For step-by-step guidance, refer to our full Act 4 Campaign Walkthrough.

Act 4 Boss Guide
The Ngamakanui Archipelago is home to numerous formidable enemies—Act 4 alone features 11 boss encounters. Thanks to its non-linear layout, you may face these bosses in a different sequence than outlined below:

  • The Prisoner

  • Scourge of the Skies

  • Great White One

  • Diamora

  • Captain Hartlin

  • Blind Beast

  • Krutog

  • Yama the White

  • Torvian

  • Benedictus

  • Tavakai

Among these, Yama the White, Benedictus (First Herald of Utopia), and both versions of Tavakai (the Chieftain / the Fallen) stand out as especially deadly. Make sure your build is prepared before engaging them!

Interludes Walkthrough
The Curse of Holten brings you back to Ogham, where you assist Renly in fighting a surge of corruption and an unnatural darkness engulfing the town of Holten. This segment delves deeper into Ezomyte lore.
Next, you return to the Vastiri Desert to support Asala in her sacred mission and encounter the Sel Khari, guardians of the Sacred Water. Traverse the sands and defeat Azmadi, the Faridun Prince, to conclude the Stolen Barya storyline.
The narrative continues with Doryani’s Contingency, where you once again aid the Vaal thaumaturge Doryani in his attempt to save his people from the Cataclysm. He suspects that ancient Vaal descendants might still survive, hidden deep within the mountains—and that they could hold the key to defeating the Beast.

Interludes Boss Guide
The Interludes feature 14 challenging boss fights, including reimagined versions of previous enemies.

Interlude 1: The Curse of Holten

  • Isolde and Heldra

  • Siora, Blade of the Mists

  • Sigbert and Godwin

  • Oswin, the Dread Warden

  • Lady Elswyth and Thane Wulfric

Interlude 2: The Stolen Barya

  • Vornas, the Fell Flame

  • Akthi and Anundr

  • Elzarah, the Cobra Lord

  • Azmadi, the Faridun Prince

Interlude 3: Doryani’s Contingency

  • Lythara, the Wayward Spear

  • The Abominable Yeti

  • Rakkar, the Frozen Talon

  • Stormgore, the Guardian

  • Zelina and Zolin

Be especially prepared for Azmadi (Interlude 2) and Lythara (Interlude 3)—both pose significant tactical challenges.